Laserterapia transcutânea para efeitos adversos hematopoiéticos de quimioterápicos antineoplásicos: Ensaio clínico randomizado

Talita Oliveira De Lima; Mayara  Spin; Rosane  De Fátima Zanirato Lizarelli; Eliana  Maria Minicucci; Karina Alexandra  Batista Da Silva Freitas; Silvia Cristina  Mangini Bocchi

doi:10.36489/nursing.2022v25i288p7826-7840

Authors

Talita Oliveira De Lima https://orcid.org/0000-0002-6617-6514
Mayara Spin https://orcid.org/0000-0003-4545-608X
Rosane De Fátima Zanirato Lizarelli https://orcid.org/0000-0003-0418-8381
Eliana Maria Minicucci https://orcid.org/0000-0002-4664-6929
Karina Alexandra Batista Da Silva Freitas https://orcid.org/0000-0002-3413-8468
Silvia Cristina Mangini Bocchi https://orcid.org/0000-0002-2188-009X

DOI:

https://doi.org/10.36489/nursing.2022v25i288p7826-7840

Keywords:

Laser therapy, Cutaneous administration, Drug-related side effects and adverse reactions

Abstract

Objective: To evaluate the effectiveness of the protocols for transcutaneous application of the Intravenous Laser Irradiation of Blood 30' and 60', on the adverse effects on hematopoietic tissue by intravenous antineoplastic chemotherapeutic agents in adults. Method. Clinical, randomized and single-blind trial, carried out in an outpatient chemotherapy service of a public hospital in the state of São Paulo, carried out from April 2018 to March 2019. The sample consisted of 55 patients with solid tumors, from the second cycle of treatment with cytotoxic intravenous drugs for hematopoietic tissue. The wavelength used was 660 nm, transcutaneously, under the radial artery. Result. Compared to the type of blood component, we obtained, respectively from the Intravenous Laser Irradiation of Blood 30' and 60' protocols: hemoglobin (85%; 86%), platelets (100%; 100%) and neutrophils (95%; 92%). Conclusion. Both protocols were considered effective and, therefore, it is suggested to implant them in chemotherapy units.

Author Biographies

Talita Oliveira De Lima

Assistant Nurse at the Hospital das Clínicas of the Faculty of Medicine of Botucatu (HCFMB). Specialist in Family Health at the Federal University of Health Sciences of Porto Alegre (UFCSPA). Master in laser therapy from Universidade Estadual Paulista. PhD student in Biophotonics applied to Health Sciences at Universidade Nove de Julho (UNINOVE). Botucatu (SP)

Mayara Spin

Nurse at Universidade Estadual Paulista (UNESP) and Resident of the Multiprofessional Residency program in Adult and Elderly Health at Hospital das Clínicas, Faculty of Medicine of Botucatu, linked to the Nursing Department. Botucatu (SP), Brazil.

Rosane De Fátima Zanirato Lizarelli

Degree in Dentistry from the University of São Paulo. Residency and Specialization in Restorative Dentistry at FORP-USP. Master in Materials Science and Engineering from the University of São Paulo. PhD in Materials Science and Engineering from the University of São Paulo and Post-Doctorate in Biophotonics from IFSC-USP and Post-Doctorate in Morphology from FORP-USP. Researcher-collaborator in the area of Biophotonics at the Physics Institute of São Carlos - USP and Director-Professor of the Laser Department of the Paulista Association of Dental Surgeons Regional in Ribeirão Preto. Ribeirão Preto (SP), Brazil.

Eliana Maria Minicucci

Dental Surgeon from the Universidade Estadual Paulista Júlio de Mesquita Filho. Master in Pathology from the Faculty of Medicine of Botucatu – UNESP. PhD in General Basics of Surgery at the Botucatu School of Medicine - UNESP. Responsible for the oncology dentistry services of the oncology-hematology and bone marrow transplant outpatient clinics, and for stomatology at the Hospital das Clínicas of the Faculty of Medicine of Botucatu. Botucatu (SP), Brazil.

Karina Alexandra Batista Da Silva Freitas

Nursing and Midwifery from the Faculty of Nursing and Midwifery of Jaú. PhD and Master in Nursing by the Nursing Department of the Faculty of Medicine of Botucatu - UNESP. Specialist in Oncology, in Pedagogical Training for Teaching, MBA in Hospital Management. Technical supervisor nurse at the oncology outpatient clinic at Hospital das Clínicas, Faculty of Medicine of Botucatu. Botucatu (SP), Brazil.

Silvia Cristina Mangini Bocchi

Nurse from Universidade do Sagrado Coração (1985), Master's in Fundamental Nursing (1994), PhD in Nursing, obtained at the University of São Paulo and Post-Doctorate at The University of British Columbia School of Nursing (2010-2011). Adjunct Professor at the Nursing Department of the Faculty of Medicine of Botucatu. Botucatu (SP), Brazil.