Efeitos do Uso de Terapia Hormonal na Menopausa na Saúde Óssea e Cardiovascular

Vitória Karoline Roma Vissoto; Victoria Caroliny Silva Sena; Bruna Moraes de Souza; Láysa Guerra de Carvalho; Alexandre Adames Jorge; Otávio Lotti Paulino; João Carlos Bizinotto Leal de Lima

doi:10.36489/nursing.2025v30i328p11591-11611

Authors

Vitória Karoline Roma Vissoto Médica residente de ginecologia e obstetrícia pelo Hospital Regional do Mato Grosso do Sul. https://orcid.org/0009-0006-4324-3346
Victoria Caroliny Silva Sena Médica pela Faculdade Morgana Potrich – FAMP. https://orcid.org/0009-0003-5582-1885
Bruna Moraes de Souza Médica pela Universidade Anhanguera UNIDERP. https://orcid.org/0009-0001-1165-7097
Láysa Guerra de Carvalho Médica pela Universidade de Rio Verde (UniRV). https://orcid.org/0000-0003-4385-4658
Alexandre Adames Jorge Médico residente de clínica médica pelo Hospital Regional Mato Grosso do Sul.
Otávio Lotti Paulino Médico residente de Endocrinologia pela Faculdade de Medicina do ABC; Hospital Estadual Mario Covas. https://orcid.org/0009-0001-7261-9369
João Carlos Bizinotto Leal de Lima Médico Ginecologista e Obstetra pela Santa Casa de Fernandópolis https://orcid.org/0000-0001-7742-8556

DOI:

https://doi.org/10.36489/nursing.2025v30i328p11591-11611

Keywords:

Menopause, Hormone therapy, Osteoporosis, Cardiovascular diseases, Women's health

Abstract

Objective: To analyze the effects of hormone therapy in menopause on bone and cardiovascular health. Method: A systematic review of the literature was conducted in the PubMed and SciELO databases, including studies published between 2003 and 2023. Twelve articles were selected according to previously defined inclusion and exclusion criteria. The data were analyzed qualitatively and synthesized in narrative form, supported by descriptive tables and graphs. Results: A consistent positive effect of
hormone therapy on maintaining bone mineral density and reducing the risk of osteoporosis and fractures was observed. Regarding cardiovascular outcomes, the findings were heterogeneous, with more evident benefits when therapy was started early and greater risks in situations of late use or in patients with associated clinical conditions. Conclusion: Hormone therapy contributes to bone protection, while its cardiovascular effects remain uncertain, reinforcing the need for individualized indication and new studies with greater methodological robustness.

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References

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